Release according to article 40 para. 1 WpHG                
            
Leverkusen, Germany (pta024/08.11.2022/15:30) - Release of Voting Rights Announcement
Voting Rights Announcement
                1. Details of issuer:                 
            
| Name: | Biofrontera AG | 
| Legal Entity Identifier (LEI): | 391200D6GFSVFGFQTL13 | 
| Street: | Hemmelrather Weg 201 | 
| Postal code: | 51377 | 
| City: | Leverkusen, Germany | 
                2. Reason for notification:                 
Acquisition / disposal of shares with voting rights
                3. Details of person subject to the notification obligation                 
Legal entity: Quirin Privatbank AG                
City of registered office, country: Berlin, Germany
4. Names of shareholder(s) holding directly 3% or more voting rights, if different from 3
                5. Date on which threshold was crossed or reached                 
02.11.2022
6. Total positions
| % of voting rights attached to shares (total of 7.a.) | % of voting rights through instruments (total of 7.b.1 + 7.b.2) | Total of both in % (7.a. + 7.b.) | Total number of voting rights pursuant to Sec. 41 WpHG | |
| New | 5.03 | 2.22 | 5.03 | 56,717,385 | 
| Previous notification (if applicable) | 4.73 | 2.22 | 4.73 | 
7. Details on total positions
a. Voting rights attached to shares (Sec.s 33, 34 WpHG)
| ISIN | Absolute direct (Sec. 33 WpHG) | Absolute indirect (Sec. 34 WpHG) | In % direct (Sec. 33 WpHG) | In % indirect (Sec. 34 WpHG) | 
| DE0006046113 | 2,854,410 | 0 | 5.03 | 0.00 | 
| Total: | 2,854,410 | 5.03 | 
b.1. Instruments according to Sec. 38 (1) no. 1 WpHG
| Type of instrument | Maturity / Expiration | Exercise or conversion period | Voting Rights Absolute | Voting Rights in % | 
| Option agreement (see note 10) | 30.11.2022 | 30.11.2022 | 1,262,092 | 2.22 | 
| Total: | 1,262,092 | 2.22 | 
b.2 Instruments according to Sec. 38 (1) no. 2 WpHG
| Type of instrument | Maturity / Expiration | Exercise or conversion period | Cash or physical transaction | Voting Rights Absolute | Voting Rights in % | |
| n/a | 0 | 0.00 | ||||
| Total: | 0 | 0.00 | 
8. Information in relation to the person subject to the notification obligation
Person subject to the notification obligation is not controlled nor does it control any other undertaking(s) that directly or indirectly hold(s) an interest in the (underlying) issuer (1.).                
            
| Name | % of voting rights (if at least 3% or more) | % of voting rights through instruments (if at least 5% or more) | Total of both (if at least 5% or more) | 
                9. In case of proxy voting according to Sec. 34 para. 3 WpHG                
(only in case of attribution of voting rights in accordance with Sec. 34 para. 1 sent. 1 No. 6 WpHG)
Date of general meeting: N/A
                10. Other useful information                
An aggregation of the financial instrument according to § 38 para. 1 no. 1 WpHG with voting rights according to § 33 WpHG is exceptionally not carried out in the present report, as the financial instrument partly relates to voting rights which are already included in the position according to § 33 WpHG (namely 2.22%). The 5.03% voting rights are composed of 2.81% owned shares and 2.22% shares assigned by security.
                Date                
07.11.2022
(end)
emitter:  Biofrontera AG                
address:  Hemmelrather Weg 201, 51377 Leverkusen                
country:  Germany                
contact person:  Investor Relations                
phone:  +49 (0) 214 87 63 20                
e-mail:  ir@biofrontera.com                
website:  www.biofrontera.com
ISIN(s): DE0006046113 (share)                
stock exchanges: regulated market in Frankfurt, Dusseldorf; free market in Stuttgart, free market in Munich; open market in Berlin, Tradegate                
other stock exchanges: US OTC
